Spinach Artichoke Grilled Cheese

Featured in: Everyday Skillet Meals

This spinach artichoke grilled cheese elevates a classic comfort sandwich with a savory, creamy filling. Fresh spinach and tender artichoke hearts combine with mozzarella, cream cheese, and Parmesan for rich, melty layers. Butter the sourdough slices and toast until golden brown and cheese flows from the edges. Ready in just 25 minutes, it's perfect paired with tomato soup for a satisfying lunch or dinner.

Updated on Sun, 18 Jan 2026 11:20:00 GMT
Golden-brown sourdough slices reveal a creamy spinach artichoke grilled cheese filling, melted and oozing.  Pin It
Golden-brown sourdough slices reveal a creamy spinach artichoke grilled cheese filling, melted and oozing. | skilletstatic.com

My favorite skillet started making this odd sizzling sound one rainy Tuesday, and I realized I'd been using it to perfect grilled cheese for nearly three years. That particular afternoon, I had leftover spinach dip in the fridge and a hunch it might work inside a sandwich. The bread crisped up darker than usual, the filling oozed everywhere, and I stood at the counter eating it with my fingers. It tasted like something you'd order at a cafe but better because I knew exactly what went into it.

I made this for my sister once when she came over unannounced, still in her scrubs from a long shift. She sat at the kitchen table without saying much, just ate the whole thing in about four minutes, then asked if I had another slice of bread. We ended up making a second round together, and she admitted she'd been living on vending machine snacks for two days. Sometimes a sandwich is just a sandwich, but sometimes it's exactly what someone needs.

Ingredients

  • Shredded mozzarella cheese: This melts beautifully and creates those long cheese pulls, but make sure to shred it yourself because pre-shredded often has anti-caking agents that make it gummy.
  • Cream cheese, softened: Let it sit on the counter for at least twenty minutes so it blends smoothly without leaving lumps in the filling.
  • Grated Parmesan cheese: The real stuff adds a sharp, nutty flavor that balances the mild mozzarella.
  • Unsalted butter, softened: Soft butter spreads evenly on bread without tearing it, and you can control the salt level in the final sandwich.
  • Fresh spinach, chopped: Baby spinach works fine, but regular spinach has more flavor once it wilts down.
  • Canned or jarred artichoke hearts, drained and chopped: Press them in a paper towel to remove extra moisture or the filling will be watery.
  • Small garlic clove, minced: One clove is enough because raw garlic can overpower everything else if you're not careful.
  • Sourdough bread: A sturdy, tangy bread holds up to the heavy filling and doesn't turn soggy in the pan.
  • Salt, black pepper, and red pepper flakes: Season carefully because the cheeses already bring saltiness, and red pepper flakes add just a whisper of heat.

Instructions

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Wilt the spinach:
Add the spinach to a medium skillet with just a splash of water and cook over medium heat for a minute or two. Drain it well by pressing it against the side of the skillet with a spoon.
Mix the filling:
Combine the spinach, artichokes, cream cheese, mozzarella, Parmesan, garlic, salt, pepper, and red pepper flakes in a bowl. Stir until everything is evenly distributed and the mixture looks creamy.
Assemble the sandwiches:
Spread the filling generously on two slices of sourdough, then press the other slices on top. Butter the outside of each sandwich so both sides are covered.
Grill until golden:
Heat a nonstick skillet over medium heat and place the sandwiches in the pan. Cook for three to four minutes on each side, pressing gently with a spatula, until the bread turns golden brown and the cheese melts completely.
Slice and serve:
Remove the sandwiches from the heat, cut them in half, and serve right away while they're still warm. The cheese will set slightly as it cools, so eating them fresh makes a difference.
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Hearty spinach artichoke grilled cheese sandwiches rest beside a bowl of warm tomato soup.  Pin It
Hearty spinach artichoke grilled cheese sandwiches rest beside a bowl of warm tomato soup. | skilletstatic.com

One winter evening, I served these with tomato soup and my neighbor's kid said it tasted like pizza and grilled cheese had a baby. That description stuck with me because it's oddly accurate. Now whenever I make it, I think of that comment and smile, because kids have a way of nailing flavors without overthinking it.

Choosing Your Bread

Sourdough is my first choice because the tangy flavor plays well with the richness of the cheese, and the crust crisps up beautifully without burning. Whole wheat or multigrain also work if you want something heartier, though they can taste a bit earthy next to the creamy filling. I've tried this on white sandwich bread, and it turned out fine but a little forgettable because the bread didn't add much character. Whatever you choose, make sure the slices are thick enough to hold the filling without falling apart.

Making It Your Own

I've added fresh basil a few times, and it brings a bright, herby note that cuts through the richness. Smoked paprika is another option if you want a subtle smoky flavor without adding actual smoke. You could also toss in sun-dried tomatoes for a bit of sweetness and chew, or swap the mozzarella for fontina if you want something with more funk. The base recipe is flexible enough that you can experiment without ruining it.

Serving and Storing

These are best eaten right away, straight from the skillet, when the cheese is molten and the bread is crisp. If you need to save leftovers, wrap them in foil and reheat in a low oven rather than the microwave, which will turn the bread rubbery. You can also make the filling ahead and keep it in the fridge for up to two days, then assemble and grill the sandwiches fresh when you're ready to eat.

  • Pair with tomato soup, a green salad, or pickles for contrast.
  • Store leftover filling in an airtight container in the fridge for up to three days.
  • Reheat assembled sandwiches in a 300-degree oven for about eight minutes to keep the bread crisp.
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A close-up view shows crispy crusts on a homemade spinach artichoke grilled cheese, steam rising. Pin It
A close-up view shows crispy crusts on a homemade spinach artichoke grilled cheese, steam rising. | skilletstatic.com

This sandwich has become my go-to when I want something that feels special without requiring much effort or planning. It's one of those recipes that makes you look like you tried harder than you actually did.

Recipe FAQs

Can I prepare the spinach-artichoke filling ahead of time?

Yes, you can make the filling up to 2 days in advance. Store it in an airtight container in the refrigerator. Let it come to room temperature before assembling and cooking the sandwiches.

What bread works best for this sandwich?

Sourdough is ideal for its tangy flavor and sturdy texture that holds the creamy filling. Whole wheat, multigrain, or thick-cut white bread are excellent alternatives that provide good structural support.

How do I prevent the bread from burning while melting the cheese?

Use medium heat and avoid turning up the temperature to rush the process. Cook 3-4 minutes per side, pressing gently. Cast iron or nonstick skillets distribute heat evenly and reduce browning too quickly.

Can I add meat to this sandwich?

Absolutely. Crispy bacon, prosciutto, or thin slices of turkey integrate beautifully with the spinach-artichoke filling. Layer the meat between the cheese mixture and bread for best results.

What pairs well with this grilled cheese?

Tomato soup is the classic pairing. You can also serve with a light salad, minestrone soup, or roasted vegetable sides for a more substantial meal.

How do I achieve maximum cheese melt?

Use a mix of cheeses with different melting points as the recipe does. Cover the skillet with a lid for the final minute of cooking on each side to trap heat and ensure the cheese melts completely.

Spinach Artichoke Grilled Cheese

Gourmet grilled cheese sandwich featuring creamy spinach and artichoke filling between crispy golden sourdough slices.

Prep Duration
15 min
Cook Duration
10 min
Total Duration
25 min
Created by Hailey Barnes


Skill Level Easy

Cuisine American

Makes 2 Portions

Dietary Info Meat-Free

What You Need

Dairy

01 1 cup shredded mozzarella cheese
02 1/2 cup cream cheese, softened
03 1/4 cup grated Parmesan cheese
04 2 tablespoons unsalted butter, softened

Vegetables

01 1 cup fresh spinach, chopped
02 1/2 cup canned or jarred artichoke hearts, drained and chopped
03 1 small garlic clove, minced

Bread

01 4 slices sourdough bread

Seasonings

01 1/4 teaspoon salt
02 1/8 teaspoon freshly ground black pepper
03 Pinch of red pepper flakes, optional

How-To Steps

Step 01

Prepare the spinach: In a medium skillet over medium heat, add spinach and a splash of water. Sauté for 1-2 minutes until wilted. Drain excess moisture and transfer to a bowl.

Step 02

Combine filling ingredients: Mix sautéed spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, garlic, salt, pepper, and red pepper flakes if using until well blended.

Step 03

Assemble sandwiches: Spread the spinach-artichoke mixture evenly onto two slices of sourdough bread. Top with remaining bread slices to form sandwiches.

Step 04

Butter the bread: Apply softened butter to the exterior surfaces of all bread slices.

Step 05

Cook the sandwiches: Heat a large nonstick skillet or griddle over medium heat. Place sandwiches in the skillet and cook for 3-4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 06

Serve: Remove from heat, slice in half diagonally, and serve immediately.

What You'll Need

  • Medium skillet
  • Mixing bowl
  • Spatula
  • Nonstick skillet or griddle
  • Knife

Allergy Details

Review all ingredients for possible allergens. If concerned, please ask a healthcare provider.
  • Contains milk from cheese and butter
  • Contains wheat from sourdough bread
  • May contain traces of soy or nuts depending on bread and cheese brands

Nutrition Details (each serving)

These figures are for reference and shouldn't replace guidance from a healthcare expert.
  • Kcal: 430
  • Fats: 24 g
  • Carbohydrates: 39 g
  • Proteins: 16 g