High Protein Italian Beef Pasta

Featured in: Single-Pan Cooking Ideas

This comforting Italian-American bake combines whole wheat pasta with extra-lean ground beef, colorful vegetables like bell peppers and spinach, and a rich tomato sauce infused with oregano and basil. Topped with melted mozzarella and Parmesan, it delivers 33g of protein per serving while keeping calories at 370.

The dish comes together in just 50 minutes, making it ideal for busy weeknight dinners or meal prep Sundays. The combination of fiber-rich whole wheat pasta, lean protein, and vegetables creates a balanced, satisfying meal that keeps you full longer.

Updated on Wed, 21 Jan 2026 08:57:00 GMT
A close-up of the High Protein Italian Beef and Pasta Bake, featuring melted mozzarella and Parmesan cheese bubbling over a savory beef and vegetable sauce.  Pin It
A close-up of the High Protein Italian Beef and Pasta Bake, featuring melted mozzarella and Parmesan cheese bubbling over a savory beef and vegetable sauce. | skilletstatic.com

My kitchen smelled like a pizzeria the first time I made this, except with the unmistakable richness of ground beef browning in the pan. I was standing there at 6 PM on a Wednesday, staring at my fitness goals and a craving for something warm and satisfying, when it hit me: why not build a pasta bake that actually delivers protein without tasting like punishment? This dish became my answer, borrowing everything I love about pizza but grounded in real vegetables and lean meat. Now it's the recipe I return to when I need to feed people something they'll actually finish.

I'll never forget serving this to my sister, who was convinced she needed something 'fancy' for her new fitness routine. She took one bite, looked at me with surprise, and went back for seconds before I'd even finished plating. That moment taught me that healthy eating doesn't have to mean sacrificing flavor or the joy of a proper meal.

Ingredients

  • Whole wheat penne or rotini (300 g): The pasta holds the sauce beautifully and adds fiber, which I've learned is just as important as the protein itself.
  • Extra-lean ground beef (450 g): This is your protein backbone—choose ground sirloin if you can find it, as the meat stays tender even after baking.
  • Onion, garlic, red bell pepper, mushrooms (fresh vegetables): These aren't fillers; they're flavor builders that sneak in nutrients while making every forkful interesting.
  • Baby spinach (100 g): It wilts into almost nothing but leaves behind iron and earthiness that rounds out the whole dish.
  • Canned crushed tomatoes (700 ml): San Marzano varieties are worth the extra dollar—I can taste the difference, and you will too.
  • Tomato paste (2 tbsp): This concentrated umami is a secret weapon; it deepens the sauce without adding liquid.
  • Dried oregano and basil (1 tsp each): Don't skip these or reduce them—they're what makes this feel Italian rather than generic.
  • Part-skim mozzarella and Parmesan (180 g total): The combination gives you stretch and tang; using both keeps the cheese flavor forward without going overboard on calories.
  • Turkey pepperoni slices (optional, 30 g): A small amount delivers that pizza-night nostalgia without doubling the fat content.

Instructions

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Heat your oven and cook the pasta:
Get your oven to 200°C (400°F) while you salt a large pot of water generously—the pasta should taste like the sea. Cook the penne until it's just tender with a slight bite, then drain it well and set it aside; wet pasta makes a soggy bake.
Brown the beef properly:
Heat a large nonstick skillet over medium-high heat and add the ground beef, breaking it apart with a wooden spoon as it cooks. This step takes about 5–7 minutes, and you'll know it's right when most of the meat is no longer pink and you can smell that rich, caramelized beef flavor.
Build your vegetable layer:
Pour off any excess fat from the pan, then add diced onion, minced garlic, red bell pepper, and mushroom slices. Sauté for 5–7 minutes, stirring occasionally, until the vegetables soften and the mushrooms release their moisture—this is where your dish gets depth.
Wilt in the spinach:
Add the baby spinach and stir constantly for about one minute; it will seem like too much green at first, then suddenly compress into almost nothing. This is perfect.
Create the sauce:
Stir in the crushed tomatoes, tomato paste, oregano, basil, chili flakes if using, salt, and pepper. Let it simmer for 5 minutes, tasting as you go and adjusting seasoning to your preference—this brief simmer lets the herbs wake up.
Combine and transfer:
Pour the cooked pasta into the beef and vegetable mixture, stirring until everything is evenly coated. Transfer the entire mixture to a lightly greased 9×13 inch baking dish, spreading it in an even layer.
Top with cheese and bake:
Sprinkle the shredded mozzarella and grated Parmesan evenly across the top, then arrange turkey pepperoni slices if you're using them. Slide into the oven for 20 minutes until the cheese is melted, bubbly, and just beginning to brown at the edges.
Finish and serve:
Remove from the oven and let it rest for 2–3 minutes before serving; this prevents it from being scalding and helps it hold its shape on the plate. Garnish with fresh basil if you have it.
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The High Protein Italian Beef and Pasta Bake, a hearty one-dish meal with whole wheat penne, lean ground beef, and fresh basil garnish.  Pin It
The High Protein Italian Beef and Pasta Bake, a hearty one-dish meal with whole wheat penne, lean ground beef, and fresh basil garnish. | skilletstatic.com

My roommate walked in while this was baking and asked if I was running a restaurant. The smell was that good—toasted cheese and herbs and something savory filling the entire apartment. I realized then that food doesn't have to be complicated or time-consuming to make someone feel cared for.

Variations That Keep Things Interesting

I've made this recipe at least fifteen times now, and I've learned that it's wonderfully flexible. For extra protein, I sometimes stir in 200 g of low-fat cottage cheese or ricotta directly into the pasta mixture before baking—it doesn't change the texture noticeably, but it pushes the protein content even higher. If you're cooking for someone with dietary restrictions, chickpea pasta or lentil-based pasta works beautifully and adds more fiber and plant-based protein. I've also added roasted zucchini, black olives, or even sun-dried tomatoes for Mediterranean nights when I want something slightly different without actually changing the dish.

Make-Ahead and Storage Wisdom

This is genuinely one of the best dishes for meal prep because it actually gets better as it sits in the refrigerator. I often assemble everything except the cheese the night before, cover it, and then just add the mozzarella and Parmesan in the morning before baking. You can also freeze the unbaked casserole for up to three months—just add about 10 extra minutes to the baking time if you're baking it straight from frozen. Leftovers keep in the fridge for four days, and reheating in a 160°C oven for 10–15 minutes brings back that fresh-from-the-oven quality better than the microwave ever could.

Serving and Pairing Ideas

This bake is genuinely complete on its own, but I've found that serving it with something fresh and acidic on the side balances the richness perfectly. A simple arugula salad with lemon and olive oil cuts through the cheese beautifully, or even just a bowl of steamed broccoli with garlic adds a textural contrast that makes the meal feel more complete. Some nights I make garlic bread on the side, and other nights I skip it entirely because one plate of this is actually quite filling—the protein keeps you satisfied without that heavy feeling you get from less balanced pasta dishes.

  • Pair with a crisp green salad to balance the richness of the cheese and meat.
  • A light red wine like Chianti complements the tomato sauce beautifully if you're having company.
  • Serve directly from the baking dish for casual family meals—it feels more welcoming than plated portions.
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A golden-brown, pizza-inspired High Protein Italian Beef and Pasta Bake, topped with turkey pepperoni slices and baked to perfection in a ceramic dish. Pin It
A golden-brown, pizza-inspired High Protein Italian Beef and Pasta Bake, topped with turkey pepperoni slices and baked to perfection in a ceramic dish. | skilletstatic.com

This recipe has become something I make without even checking my notes anymore—it's become muscle memory and comfort in equal measure. There's real satisfaction in feeding yourself and the people you care about something that's genuinely good for you and honestly delicious.

Recipe FAQs

Can I make this bake ahead of time?

Absolutely. Assemble the entire dish up to 24 hours in advance, cover tightly, and refrigerate. When ready to bake, add 5-10 minutes to the cooking time if baking cold from the refrigerator.

What pasta shapes work best?

Penne and rotini are excellent choices because their ridges and curves hold the sauce well. Other short pasta like ziti, fusilli, or macaroni also work beautifully in this bake.

Can I freeze leftovers?

Yes, this freezes exceptionally well. Portion cooled leftovers into airtight containers and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat in the microwave or oven until hot throughout.

How can I increase the protein content further?

Stir in 200g of low-fat cottage cheese or ricotta before baking, use legume-based pasta, or add a layer of shredded chicken. You can also top with additional Parmesan for an extra protein boost.

What vegetables can I substitute?

Swap mushrooms for eggplant, add roasted zucchini, or include black olives for Mediterranean flair. Diced carrots or chopped kale also work well—just adjust cooking times so vegetables soften properly.

Is this suitable for gluten-free diets?

Simply substitute chickpea pasta, lentil pasta, or certified gluten-free wheat pasta for the whole wheat variety. All other ingredients are naturally gluten-free, making this an easy adaptation.

High Protein Italian Beef Pasta

Hearty pasta bake loaded with lean beef, vegetables, and melted cheese for a protein-packed dinner.

Prep Duration
20 min
Cook Duration
30 min
Total Duration
50 min
Created by Hailey Barnes


Skill Level Easy

Cuisine Italian-American

Makes 6 Portions

Dietary Info None specified

What You Need

Pasta

01 10.5 oz whole wheat penne or rotini pasta

Beef & Vegetables

01 1 lb extra-lean ground beef
02 1 medium onion, diced
03 2 cloves garlic, minced
04 1 red bell pepper, diced
05 3.5 oz mushrooms, sliced
06 3.5 oz baby spinach

Sauce

01 24 fl oz canned crushed tomatoes
02 2 tablespoons tomato paste
03 1 teaspoon dried oregano
04 1 teaspoon dried basil
05 0.5 teaspoon chili flakes, optional
06 Salt and freshly ground black pepper to taste

Cheese & Toppings

01 5 oz part-skim mozzarella cheese, shredded
02 1 oz grated Parmesan cheese
03 1 oz turkey pepperoni slices, optional
04 Fresh basil for garnish, optional

How-To Steps

Step 01

Preheat oven: Preheat oven to 400°F.

Step 02

Cook pasta: Cook pasta in a large pot of boiling salted water until al dente. Drain and set aside.

Step 03

Brown ground beef: In a large nonstick skillet over medium heat, cook the ground beef until browned, breaking it up as it cooks. Drain excess fat if needed.

Step 04

Sauté vegetables: Add onion, garlic, bell pepper, and mushrooms to the skillet. Sauté for 5 to 7 minutes until softened.

Step 05

Wilt spinach: Stir in spinach and cook until wilted, about 1 minute.

Step 06

Build sauce: Add crushed tomatoes, tomato paste, oregano, basil, chili flakes, salt, and pepper. Simmer for 5 minutes, allowing flavors to meld.

Step 07

Combine pasta and sauce: Combine the cooked pasta with the beef and vegetable sauce mixture.

Step 08

Transfer to baking dish: Transfer the mixture to a lightly greased 9x13 inch baking dish.

Step 09

Add cheese topping: Sprinkle mozzarella and Parmesan evenly over the top. Arrange turkey pepperoni slices if using.

Step 10

Bake: Bake for 20 minutes, until cheese is melted and bubbly.

Step 11

Garnish and serve: Garnish with fresh basil before serving, if desired.

What You'll Need

  • Large pot
  • Large nonstick skillet
  • 9x13 inch baking dish
  • Mixing spoon
  • Cheese grater

Allergy Details

Review all ingredients for possible allergens. If concerned, please ask a healthcare provider.
  • Contains wheat from pasta
  • Contains milk from cheese and optional cottage or ricotta cheese
  • May contain soy from processed meat or cheese labels

Nutrition Details (each serving)

These figures are for reference and shouldn't replace guidance from a healthcare expert.
  • Kcal: 370
  • Fats: 11 g
  • Carbohydrates: 37 g
  • Proteins: 33 g